Life cycle of bird flu virus




















Our analyses revealed that during late summer staging July-August and fall migration September-October , hatch year HY birds were more likely to be infected than after hatch year AHY birds, however there was no difference between age categories for the remainder of the year winter, spring migration, and breeding period , likely due to maturing immune systems and newly acquired immunity of HY birds. Probability of infection increased non-linearly with latitude, and was highest in late summer prior to fall migration when densities of birds and the proportion of susceptible HY birds in the population are highest.

In a few cases, bird flu has passed from one person to another. Only sporadic human cases have been reported since Health officials worry that a global outbreak could occur if a bird flu virus mutates into a form that transmits more easily from person to person. Researchers are working on vaccines to help protect people from bird flu. Signs and symptoms of bird flu may begin within two to seven days of infection, depending on the type.

In most cases, they resemble those of conventional influenza, including:. Some people also experience nausea, vomiting or diarrhea. And in a few cases, a mild eye infection conjunctivitis is the only indication of the disease.

See your doctor immediately if you develop a fever, cough and body aches and have recently traveled to a part of the world where bird flu occurs. Be sure to let your doctor know if you visited any farms or open-air markets.

Bird flu occurs naturally in wild waterfowl and can spread into domestic poultry, such as chickens, turkeys, ducks and geese. The disease is transmitted via contact with an infected bird's feces, or secretions from its nose, mouth or eyes.

Open-air markets, where eggs and birds are sold in crowded and unsanitary conditions, are hotbeds of infection and can spread the disease into the wider community. Undercooked poultry meat or eggs from infected birds can transmit bird flu. Poultry meat is safe to eat if it's been cooked to an internal temperature of F 74 C. Influenza A subtypes and B viruses are further classified by strains. The nomenclature for influenza virus isolates includes the influenza virus type A or B , host species omitted if human in origin , geographical site, serial number, year of isolation and, lastly, the H and N variants in brackets.

Influenza viruses have a single-stranded, negative-sense RNA genome and a pleiomorphic non-uniform envelope with a diameter of 50— nm. The influenza A and B virus genomes consist of 8 separate segments, each coding for 1 or several functionally important proteins required for virus entry, replication or virus structure.

HA binds to its cellular receptor, sialic acid N-acetyl-neuraminic acid. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem. Early steps of the conformational change of influenza virus hemagglutinin to a fusion active state: stability and energetics of the hemagglutinin. Biochim Biophys Acta. Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds.

Influenza virus M2 protein has ion channel activity. The M2 proton channels of influenza A and B viruses. Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes. Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication. Promoter elements in the influenza vRNA terminal structure. Functional analysis of the influenza A virus cRNA promoter and construction of an ambisense transcription system.

Absence of detectable capping and methylating enzymes in influenza virions. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures. Nonviral oligonucleotides at the 5' terminus of cytoplasmic influenza viral mRNA deduced from cloned complete genomic sequences. Cap and internal nucleotides of reovirus mRNA primers are incorporated into influenza viral complementary RNA during transcription in vitro. Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcription.

Nucleic Acids Res. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J. Influenza A virus and the cell nucleus. Functional association between viral and cellular transcription during influenza virus infection. Rev Med Virol. Genes Dev. Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components. J Gen Virol. The influenza virus panhandle is involved in the initiation of transcription.

Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity. Polyadenylation sites for influenza virus mRNA. Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export. Mol Cell. Influenza virus gene expression: control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs.

In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein. Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies.



0コメント

  • 1000 / 1000